Benefits of kinetin and how to make your own kinetin cream
Kinetin (6-furfurylaminopurine) is a derivative of adenine, one of the nucleic acid bases that form DNA and RNA. Kinetin would be more effective if you were a plant looking to grow some shoots, but it has some benefits for human skin.
Figure. Kinetin (6-furfurylaminopurine)
Kinetin on human skin
Kinetin (a chemical with plant hormone activity) and zeatin (a natural plant hormone) have been shown to have some growth-modulating, antioxidative and antisenescence effects in human skin cells. Kinetin application also stimulated the formation of elastin and fibrillin-1 deposition in the upper dermis and stimulated their perpendicular organization to the dermo-epidermal junction. Kinetin may affect keratinocyte differentiation to improve skin moisture content, trans-epidermal water loss, and other signs of skin aging.
DIY
Add some kinetin to a base cream like Canvas base cream.
Kinetin is not all your skin needs. When you make your DIY skincare product, take advantage of what Skin Actives offers you and also add antioxidants, growth factor and nutrition in general.
Human proteins for human cells
Zeatin is a natural plant hormone. Guess what human skin uses? Epidermal growth factor! So instead of playing with kinetin,m how about you add some EGF to your base cream? Just saying, it’s so nice when the mechanism of action is elucidated so clearly!
References
Amasino R. 1955: kinetin arrives: the 50th anniversary of a new plant hormone. Plant Physiol. 2005;138(3):1177-1184. doi:10.1104/pp.104.900160
Wu, J. J, Weinstein, G. D.; Kricorian, G. J.; Kormeili, T.; McCullough, J. L. (2007) Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea Clinical & Experimental Dermatology, 6: 693-695. doi: 10.1111/j.1365-2230.2007.02513.x.
Rattan SI, Clark BF. (1994) Kinetin delays the onset of ageing characteristics in human fibroblasts. Biochem Biophys Res Commun 201: 665–72. doi: 10.1006/bbrc.1994.1752.
Jabłońska-Trypuć, A., Matejczyk, M., & Czerpak, R. (2016). N6-benzyladenine and kinetin influence antioxidative stress parameters in human skin fibroblasts. Molecular and Cellular Biochemistry, 413, 97–107. doi:10.1007/s11010-015-2642-5
An S, Cha HJ, Ko JM, et al. (2017) Kinetin Improves Barrier Function of the Skin by Modulating Keratinocyte Differentiation Markers. Ann Dermatol. 29:6-12. doi:10.5021/ad.2017.29.1.6
Olsen A, Siboska GE, Clark BF, Rattan SI. (1999) N(6)-Furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA. Biochem Biophys Res Commun. 265:499–502.
Verbeke P, Siboska GE, Clark BF, Rattan SI. (2000) Kinetin inhibits protein oxidation and glycoxidation in vitro. Biochem Biophys Res Commun. 276:1265–1270.
Berge U, Kristensen P, Rattan SI. (2006) Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro. Ann N Y Acad Sci. 1067:332–336.
Chiu PC, Chan CC, Lin HM, Chiu HC. (2007) The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J Cosmet Dermatol. 6:243–249.